Tunisia says suicide bomber carried out bus attack claimed by Islamic State

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Neuronal plasticity, its mechanistic basis, how it contributes to the normal and abnormal functions of the nervous system, and how it can be a target for therapy comprise the major focus of Dr. Specifically, he studies neural plasticity in relation to pain, regeneration, neurodegenerative disorders and developmental neurobiology. Woolf has spearheaded discoveries on how functional synaptic plasticity, structural reorganization of synaptic architecture, injury-induced transcriptional changes, neuro-immune interactions and activity-dependent loss of interneurons all contribute to the pathogenesis and maintenance of pain.

He has linked polymorphisms in human genes with the risk of developing pain and has pioneered new ways of phenotyping pain in patients. His work has led to the identification of novel targets for analgesics, and, with Bruce Bean at HMS, he has discovered a way of producing a long-lasting local analgesia. With Lee Rubin at HU, he has converted human embryonic stem cells into pain neurons for disease modeling and testing analgesics and with Josef Penninger used genome-wide screens in Drosophila to identify novel pain genes.

Additionally, Dr. Woolf has explored how axonal injury activates a survival and regeneration program in sensory and motor neurons, and he has identified the transcription factors that act as master regulators of these. This has led to novel genetic approaches to increase regeneration and ameliorate motor neuron disease. Most of this work is focused on primary sensory and spinal cord neurons, which are studied using a multidisciplinary approach that spans mouse and human genetics, molecular and cell biology, bioinformatics, synaptic electrophysiology, neuroanatomy, integrative systems biology and behavior.

The lab represents a complex mixture of basic and translational neuroscience and works closely with a wide number of academic groups and the pharmaceutical and biotechnology industry to identify and validate molecular targets for novel analgesics and axonal growth determinants. Woolf moved to England in He worked at University College London for close on 20 years, towards the latter part as a Professor of Neurobiology.

In , Dr.

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TUNIS Reuters – Tunisian authorities said on Wednesday a suicide bomber wearing a vest packed with plastic explosive blew up a presidential guard bus a day earlier, killing at least 12 troops in an attack claimed by Islamic State militants. It was the first suicide bombing in the capital. In October a bomber blew himself up on a beach in Sousse, and previously an al Qaeda suicide bomber attacked the synagogue in Djerba, killing 21 people. It included a photograph of a man, wearing a headscarf, a white robe and bomb vest, who it said was the bomber and named him as Abu Abdyllah Tounsi.

The name suggests he was Tunisian himself. An Interior Ministry statement said 12 guards died in the blast of Semtex explosive located in a belt the bomber was wearing. The explosives had been traced to Libya, it said. Another body at the scene was probably that of the bomber. Security officials said the bomber detonated his blast just as presidential guards were boarding a bus on Mohamed V Avenue to travel to the presidential palace for duty.

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