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Neuronal plasticity, its mechanistic basis, how it contributes to the normal and abnormal functions of the nervous system, and how it can be a target for therapy comprise the major focus of Dr. Specifically, he studies neural plasticity in relation to pain, regeneration, neurodegenerative disorders and developmental neurobiology. Woolf has spearheaded discoveries on how functional synaptic plasticity, structural reorganization of synaptic architecture, injury-induced transcriptional changes, neuro-immune interactions and activity-dependent loss of interneurons all contribute to the pathogenesis and maintenance of pain.
He has linked polymorphisms in human genes with the risk of developing pain and has pioneered new ways of phenotyping pain in patients. His work has led to the identification of novel targets for analgesics, and, with Bruce Bean at HMS, he has discovered a way of producing a long-lasting local analgesia. With Lee Rubin at HU, he has converted human embryonic stem cells into pain neurons for disease modeling and testing analgesics and with Josef Penninger used genome-wide screens in Drosophila to identify novel pain genes.
Additionally, Dr. Woolf has explored how axonal injury activates a survival and regeneration program in sensory and motor neurons, and he has identified the transcription factors that act as master regulators of these. This has led to novel genetic approaches to increase regeneration and ameliorate motor neuron disease. Most of this work is focused on primary sensory and spinal cord neurons, which are studied using a multidisciplinary approach that spans mouse and human genetics, molecular and cell biology, bioinformatics, synaptic electrophysiology, neuroanatomy, integrative systems biology and behavior.
The lab represents a complex mixture of basic and translational neuroscience and works closely with a wide number of academic groups and the pharmaceutical and biotechnology industry to identify and validate molecular targets for novel analgesics and axonal growth determinants. Woolf moved to England in He worked at University College London for close on 20 years, towards the latter part as a Professor of Neurobiology.
In , Dr.
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Moon agreed with the need to maintain pressure on the North until it denuclearizes, but said such pressure could be or should be eased to encourage the impoverished North. Moon’s remarks come amid an apparent tug of war between the United States and North Korea over when the North should be entitled to rewards for giving up its nuclear ambition. Pyongyang is said to be demanding timely rewards for what it claims to be irreversible denuclearization steps it has already taken while Washington is insisting on maximum sanctions and pressure until the impoverished nation fully denuclearizes.
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I combine administrative and survey data to characterize the current functioning of the property tax in the urban region of Dakar Senegal. This paper aims to assess the Property Tax Gap; to identify determinants of being in the tax net; and finally to discuss whether a weakly functioning property tax ends up being more or less progressive than the theoretically not progressive tax defined by the legal framework.
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TUNIS Reuters – Tunisian authorities said on Wednesday a suicide bomber wearing a vest packed with plastic explosive blew up a presidential guard bus a day earlier, killing at least 12 troops in an attack claimed by Islamic State militants. It was the first suicide bombing in the capital. In October a bomber blew himself up on a beach in Sousse, and previously an al Qaeda suicide bomber attacked the synagogue in Djerba, killing 21 people. It included a photograph of a man, wearing a headscarf, a white robe and bomb vest, who it said was the bomber and named him as Abu Abdyllah Tounsi.
The name suggests he was Tunisian himself. An Interior Ministry statement said 12 guards died in the blast of Semtex explosive located in a belt the bomber was wearing. The explosives had been traced to Libya, it said. Another body at the scene was probably that of the bomber. Security officials said the bomber detonated his blast just as presidential guards were boarding a bus on Mohamed V Avenue to travel to the presidential palace for duty.
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The assessment of seed vigor has many important implications to the seed industry as a basic monitoring of seed physiological potential during different phases of seed production and a support for strategic decisions regarding the selection of high quality seedlots to meet the consumer demand. The potential attributes of seed vigor as a fundamental physiological seed characteristic and its association with field stand establishment and crop productivity has been worldwide recognized from the s onward.
This led to the diversification of research approaches involving the synchronization of different physiological characteristics and events that determine the potential for high performance during seed storage and after sowing. The basic objective of vigor testing is to provide a consistent identification of differences in physiological potential among seedlots of commercial value and this represents a more sensitive parameter than the germination test.
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This work is in the public domain in its country of origin and other countries and areas where the copyright term is the author’s life plus years or fewer. This work is in the public domain in the United States because it was published or registered with the U. Copyright Office before January 1, This file contains additional information such as Exif metadata which may have been added by the digital camera, scanner, or software program used to create or digitize it. If the file has been modified from its original state, some details such as the timestamp may not fully reflect those of the original file.
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